PROGRAM OF THE INTERNATIONAL CONFERENCE

“TOOLKITS FOR DNA VACCINE DESIGN, AN UPDATE” Moscow, November 17-21, 2016

Thursday November 17, 2016

09.00-10.00 Registration at the Mechninov´s Institute of Vaccine and Sera, Mali Kazenny pereulok 5a, building 9.

10.00-10.15 Opening

Welcome by Prof, Academician Zverev Vitaly V, the Director of the Mechnikov´s Institute of Vaccine and Sera

10.15-11.00 SESSION I: DNA AND OTHER VACCINE MODALITIES

Shneider Alexander (CureLab Oncology, Inc., Boston, USA; University of Ariel, Ariel, Israel; OOO CL Oncology, Moscow, Russia) (key-note 45 min)

Can a DNA cancer vaccine turn out to be an anti-inflammatory gene therapy?

11.00-11.30 COFFEE-BREAK Mali Kazenny pereulok 5a, building 16 & POSTER VIEWING

11.30-13:00 SESSION I: DNA AND OTHER VACCINE MODALITIES (continuation)

Sominskaya Irina (Biomedical Research and Study Center, Riga, Latvia) (key-note 30 min)

Protein against DNA, a review of vaccines against hepatitis B virus

Joan Joseph (Fundacio Clinic, Barcelona, Spain) (key-note 30 min)

Pre-clinical development of recombinant BCG based HIV vaccine. Lessons learned

Žusinaite Eva (Institute of Technology, Tartu University, Tartu, Estonia) (20 min)

Progress in Zika virus vaccine development

13.00-14.00 LUNCH Mali Kazenny pereulok 5a, building 16

14.00-15.30 SESSION II: DESIGN AND PRECLINICAL TESTING OF DNA VACCINES

Lukashev Alexander (MP Chumakovs´s Federal Research Center for Study and Development of Immunobiological Preparations, Moscow, Russia) (30 min)

Viral RNA nucleotide content is affected by innate immune system recognition – implications for vector design

Isaguliants Maria (Riga Stradins University, Riga, Latvia; Karolinska Institutet. Stockholm, Sweden; MP Chumakovs´s Federal Research Center for Study and Development of Immunobiological Preparations, and Gamaleya Research Center of Epidemiology and Microbiology, Moscow, Russia) (30 min)

HIV enzymes as prototype immunotherapeuticals against drug resistance: preclinical trials in mice

Latanova Anastasia (WA Englehardt Institute of Molecular Biology, Moscow, Russia; Karolinska Institutet, Stockholm, Sweden) (20 min)

Multicomponent DNA vaccine based on HIV-1 clade A enzymes induces cellular response of diverse profile in mice

15.30-16.00 COFFEE-BREAK Mali Kazenny pereulok 5a, building 16 & POSTER VIEWING

16.00-17.00 SESSION II: DESIGN AND PRECLINICAL TESTING OF DNA VACCINES (continuation)

Starodubova Elizaveta (WA Englehardt Institute of Molecular Biology, Moscow, Russia; Karolinska Institutet, Stockholm, Sweden) (30 min)

Optimization of design and delivery of HIV reverse transcriptase based prototype DNA vaccines in a mouse model

Pankova Ekaterina (WA Englehardt Institute of Molecular Biology, Moscow, Russia) (short oral, 15 min)

Single immunization with codon-optimized gene of consensus rabies virus glycoprotein is able to elicit neutralizing antibodies in mice

Dovbenko Anastasija (Biomedical Research and Study Center, Riga, Latvia) (poster presentation*, 7 min)

Comparison of immunogenicity of HCV core and its alternative reading frame protein in mice

Starodubova Elizaveta (WA Englehardt Institute of Molecular Biology, Moscow, Russia; Karolinska Institutet. Stockholm, Sweden) (poster presentation*, 7 min)

Comparative immunogenicity of HIV-1 reverse transcriptase of clades A and B in mice

* Short presentation of the materials of the poster; poster viewed throughout the conference.

Friday November 18, 2016

07.45 Transportation by buss of conference participants to the Chumakov´s Institute of poliomyelitis, Moscovsky Settlement.

OBS! Only for registered conference participants. Preference to participants staying at hotel Agios.

08.45-09.15 Registration at the MP Chumakovs´s Federal Research Center for Study and Development of Immunobiological Preparations, Moskovsky Settlement, Moscow.

09.15-09.30

Welcome by Prof, Academician Ishmukhametov Aidar A, the Director of the MP Chumakovs´s Federal Research Center for Study and Development of Immunobiological Preparations

09.30-11.30 SESSION III: DNA DELIVERY AND ADJUVANTS

Shneider Alexander (CureLab Oncology, Inc., Boston, USA; University of Ariel, Ariel, Israel; OOO CL Oncology, Moscow, Russia) (45 min)

Adjuvants for DNA vaccines: from ad hock vaccine design to technology platforms

Rhee Joon Haeng (Chonnam National University Medical School, Gwangju, Republic of Korea) (invited oral, 30 min)

Adjuvants and their application: Update and the flagellin case

Dzmitruk Volha (Institute of Biophysics and Cell Engineering of NASB, Minsk, Belarus) (key-note, 30 min) Dendrimer complexes as a platform for gene delivery

Gordeychuk Ilya (MP Chumakovs´s Federal Research Center for Study and Development of Immunobiological Preparations; Karolinska Institutet, Stockholm, Sweden) (15 min)

Visualization and quantification of protein expression after gene electroporation in vivo

11.30-12.00 COFFEE-BREAK

12.00-13.40 SESSION IV: VACCINE PRODUCTION AND CLINICAL TRIALS

Kozlov Andrei (The Biomedical Center and Peter the Great Polytechnic University, St Petersburg, Russia)

(key-note, 45 min)

The Results of Phase II Clinical Trial of HIV Therapeutic Optimized DNA Vaccine: The Possible Reach of Viral Reservoirs

Karpenko Larisa (State Research Center of Virology and Biotechnology “Vector”, Koltzovo, Novosibirsk, Russia) (30 min)

Vaccines against HIV-1 and other infectious and somatic diseases, developed in State Research Center of Virology and Biotechnology “Vector”

Chubarev Vladimir (Institute of Pharmacy and Translational Medicine, IM Sechenov First Moscow State Medical University, Moscow, Russia) (20 min)

The development of research universities as a new business model for production of innovative vaccines

Blinkova Larisa P (Mechnikov Research Institute for Vaccine and Sera, Moscow, Russia) (poster presentation*, 7 min)

Detection and resuscitation of viable but nonculturable bacteria in vaccines and other biomedical preparations

13.40-14.40 LUNCH

14.40-16.20 SESSION V: NOVEL TREATMENTS AND TECHNIQUES

Guryeva Svetlana (IM Sechenov First Moscow State Medical University, Moscow, Russia) (20 min)

Spidroin-based bioartificial matrix with therapeutic agents for regenerative medicine

Zamyatnin Jr. Andrey (IM Sechenov First Moscow State Medical University, Moscow, Russia) (20 min)

Targeting at gluten intolerance culprit: development of enzymatic tools for effective gluten detoxification

Michlewska Sylwia & Maksim Ionov (Lodz University, Lodz, Poland) (20 min)

Ruthenium dendrimers as anticancer delivery agents

Kalis Martins (Riga Stradins University, Riga, Latvia) (20 min)

Determination of parameters defining accuracy of widefield FRET measurements of molecular interactions

Osmakov Dmitry (IM Sechenov First Moscow State Medical University, Moscow, Russia) (poster * , 7 min)

Low molecular weight compounds inhibiting the acid-sensing ion channels

Zernii Evgeni (Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University) (poster presentation*, 7 min)

Antioxidant premedication as a new approach to prevention of perioperative corneal abrasions

* Short presentation of the materials of the poster; poster viewed throughout the conference.

16.20-16.50 COFFEE & MINGLE

17:00 Transportation of conference participants by buss from Federal Research Center, Moscovsky Settlement, to hotel Agios

18.30-21.30 Conference dinner at the restaurant “Zolotya Ribka”, address: ulitza Solyanka 11/6-1

Saturday November 19, 2016

Mechninov´s Institute of Vaccine and Sera, Mali Kazenny pereulok 5a, building 9

10.00-11.20 SESSION VI: MOLECULAR MECHANISMS BEHIND DNA VACCINATION

Östlund Farrant Anna-Karin (Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden) (key note, 40 min)

The packaging of chromosomes, epigenome is a regulator of nuclear processes

Belikov Sergey (Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden) (key note, 40 min)

Regulation of transcription, exploiting advances in genome biology to understand and program immune response

11.20-11.50 COFFEE-BREAK Mali Kazenny pereulok 5a, building 16 & POSTER VIEWING

11.50-13.00 SESSION VI: MOLECULAR MECHANISMS BEHIND DNA VACCINATION

Rhee Joon Haeng (Chonnam National University Medical School, Gwangju, Republic of Korea) (key note, 40 min)

Adjuvants: 21st century toolkit for vaccines and immunotherapeutics, with a special emphasis on mucosal routes

Jansons Juris (Riga Stradins University, and Biomedical Research and Study Center, Riga, Latvia) (20 min)

Delivery and immunogenic performance of naked DNA vaccines visualized by in vivo imaging of a novel near-infrared fluorescent reporter

13.00-14.00 LUNCH Mali Kazenny pereulok 5a, building 16

14.00-15.30 SESSION VII: MOLECULAR MECHANISMS BEHIND DNA VACCINATION, IMMUNE ASPECTS

Westerberg Lisa (Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden) (key note, 40 min)

DNA vaccination to activate the adaptive immune system to fight cancer

Reche Pedro (Complutense University of Madrid, Madrid, Spain) (key note, 40 min)

Epitope-based vaccines and the educated search for epitopes

15.30-16:00 COFFEE-BREAK Mali Kazenny pereulok 5a, building 16 & POSTER VIEWING

16:00-17:15 SESSION VIII: IMMUNE RESPONSE TO INFECTIONS AND CANCER

Kilpeläinen Athina (Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden; and Fundacio Clinic, Barcelona, Spain) (short oral, 15 min)

Murine breast adenocarcinoma cells expressing HIV proteins as a challenge model to test the efficacy of therapeutic HIV vaccines

Prostova Maria (MP Chumakovs´s Federal Research Center for Study and Development of Immunobiological Preparations, Moscow, Russia) (short oral, 15 min)

Immunogenicity of poliovirus non-structural proteins during natural poliovirus infection

Kichatova Vera (Russian Medical Academy of Postgraduate Education, and Mechnikov Research Institute for Vaccines and Sera, Moscow, Russia) (20 min)

Analysis of prevalence of substitutions in amino acid positions 70 and 91 of viral nucleocapsid associated with the sustained virologic response to interferon therapy in chronic hepatitis C.

Podschwadt Philip (Ulm University, Ulm, Germany) (poster presentation*, 7 min)

Polarized macrophages use veiled surface structures to ingest HIV particles

Sander Philip (Ulm University, Ulm, Germany) (20 min)

Monitoring cell death of glioblastoma cells and immune cell interactions by IncuCyteZOOM

* Short presentation of the materials of the poster; poster viewed throughout the conference.

Sunday November 20, 2016

Mechninov´s Institute of Vaccine and Sera, Mali Kazenny pereulok 5a, building 9

10:00-11:30 SESSION IX: MOLECULAR MEDICINE: CANCER

Ustinova Monta (Riga Stradins University, Riga, Latvia) (short oral, 15 min)

The impact of 11 low-penetrance allelic variants on breast cancer morbidity in population of Latvia

Alekseeva Ekaterina (IM Sechenov First Moscow State Medical University, Moscow, Russia) (poster * , 7 min)

Structural pathology of the 10q23.3-26.3 chromosome region in glioblastoma

Kalnina Lelde (Riga Stradins University, Riga, Latvia) (short oral, 15 min)

The FABP5 gene expression is significantly higher in triple-negative sporadic than hereditary breast cancer tissues

Mezale Dzeina (Riga Stradins University, Riga, Latvia) (short oral, 15 min)

Expression of p53 protein in primary and secondary malignant liver tumors

Osminin Sergey (IM Sechenov First Moscow State Medical University, Moscow, Russia) (poster *, 7 min)

Abnormal methylation MGMT, CDH1, p16/CDKNA2, DAPK, RAR-B genes in patients with Barretts oesophagus before and after surgical treatment

Potoldykova Natalia (IM Sechenov First Moscow State Medical University, Moscow, Russia) (poster *, 7 min)

Analysis of telomerase activity in order to develop non-invasive diagnosis of bladder cancer

Kuznetsova Ekaterina (IM Sechenov First Moscow State Medical University, Moscow, Russia) (poster *, 7 min)

Methylation of matrix and transmembrane proteins encoding genes in breast cancer

Round table discussion on student and PhD student research activities and possibilities for collaboration

* Short presentation of the materials of the poster; poster viewed throughout the conference.

11.30-12.00 COFFEE-BREAK Mali Kazenny pereulok 5a, building 16 & MINGLE

Excursions can be organized on the request and at the cost of conference participants. Please, contact Maria Isaguliants to book maria.issagouliantis@ki.se

Monday November 21, 2016

Institute of Molecular Medicine, I.M. Sechenov First Moscow State Medical University, Trubetskaya ulitsa 8, building 2.

10:00-13:30 MOLECULAR MEDICINE WORKSHOP

Östlund Farrant AK (Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden) (invited oral, 30 min)

Differential response to malaria in two ethnic groups in Sub-Saharan Africa

Belikov Sergey (Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden) (invited oral, 30 min)

Quantification of transcription factor-­DNA binding affinity in a living cell

Rhee Joon Haeng (Chonnam National University Medical School, Gwangju, Republic of Korea) (invited oral, 30 min)

Flagellin as a versatile adjuvant for vaccines against intractable diseases

Manuylov Victor (IM Sechenov First Moscow State Medical University, Moscow, Russia) (short oral, 15 min)

Genetic and serological diversity of hepatitis B virus in Siberia, Russia

11.00-11.30 COFFEE, MINGLE

Westerberg Lisa (Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden) (invited oral, 30 min)

Understanding how Wiskott-Aldrich syndrome protein (WASp) stings in immune cells

Shneider Alex (CureLab Oncology, Inc., Boston, USA; University of Ariel, Ariel, Israel; OOO CL Oncology, Moscow, Russia) (invited oral, 30 min)

Anti-inflammatory gene therapy

Mikhaylenko Dmitry (Institute of Molecular Medicine, IM Sechenov First Moscow State Medical University, Moscow, Russia) (short oral, 15 min)

Mutation and gene expression analysis of urine sediments in non-invasive molecular genetic diagnostics of the common oncourological diseases

Kazakova Svetlana (IM Sechenov First Moscow State Medical University, Moscow, Russia) (short oral, 15 min)

Identification of aberrant DNA methylation in paediatric acute myeloid leukaemia by multiplex methylation sensitive PCR

Zamyatnin Jr Andrey (IM Sechenov First Moscow State Medical University, Moscow, Russia) (30 min)

Academic activities within Sechenov First Moscow State University

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