Approximately one out of eight human cancers has a viral etiology. Viral cancers present unique opportunities for prophylaxis, diagnosis, and therapy, as demonstrated by the success of HBV and HPV vaccines and HCV antivirals in decreasing the incidence of tumors that are caused by these viruses.

For other chronic viral infections and related cancers, problems still dominate over the progress. Prophylactic HPV vaccination does not cure already established infections, urgently requesting development of therapeutic HPV vaccines. Several are in pipeline, but still far from actual application for treatment of HPV-related cancers. Development of HCV vaccines is in progress, but is hampered by HCV variability and absence of longitudinal sterilizing anti-viral response. The success of antiretroviral therapy in controlling HIV-1 replication and immune reconstitution did not lead to significant reduction of HIV-1 associated cancers indicating alternative mechanisms of their development, not connected to immune suppression.

Symposium will unravel the progress in the studies of the molecular pathogenesis of chronic viral infections, cover common mechanisms of action of human oncogenic viruses, such as the activity of viral oncoproteins, induction of genomic instability, support of chronic inflammation, and modulation of tumor microenvironment. Special attention will be devoted to virus-induced alterations in the functions of immune system, induction of innate and adaptive immune responses including the relationship between metabolism and the immune response to viral infections, and immunometabolism on the cellular level. In-depth understanding of these processes would create new openings to the design of novel viral vaccines and immunotherapies.

Abstracts and selected papers will be published in a special issue of

“INFECTIOUS AGENTS AND CANCER”, BMC journal (Springer Nature), Q2 in Infectious Diseases; IF Web of Science 2.7; IF Scopus 4.3 https://infectagentscancer.biomedcentral.com/about

On behalf of Organizing Committee

Maria Isaguliants (Issagouliantis)

Associate Prof,

Karolinska Institutet, Stockholm, Sweden & Riga Stradins University, Riga, Latvia

Contact info – maria.issagouliantis@rsu.lv

International On-line Symposium “Chronic viral infections and cancer, openings for vaccines”

DAY 1, DECEMBER 16, 2021 13.30-19.45 (GMT+3)

13.30-14.10 OPENING

OPENING LECTURE (pending)

Natalia Bocharova (BD Biosciences, Moscow, Russia) DISCOVERING NEW BIOLOGY WITH MULTIOMIC SINGLE CELL SEQUENCING (Sponsor presentation) (10 min)

SESSION 1. MOLECULAR PATHOGENESIS OF CHRONIC VIRAL INFECTIONS

14.10-15.00 Section 1.1 Chronic viral infections and oxidative stress

PLENARY LECTURE Alexander Ivanov (Englehardt Institute of Molecular Biology) CHRONIC VIRAL INFECTIONS AND OXIDATIVE STRESS (30 min)

Short oral (10 min)

Short oral (10 min)

15.00-16.30 Section 1.2 Metabolic signatures of chronic viral infections

PLENARY LECTURE Birke Bartosch (Cancer Research Center of Lyon, Lyon, France) METABOLIC CHANGES IN VIRAL INFECTIONS (30 min)

Oral (15 min)

Oral (15 min)

Short oral (10 min)

Short oral (10 min)

Discussion & Break (10 min)

SESSION 2. CHRONIC VIRAL INFECTIONS AND CANCER

16.30-17.30 Section 2.1 Mechanisms of viral oncogenicity

PLENARY LECTURE Maria Lina Tornesello (Istituto Nazionale Tumori – IRCCS Fondazione Pascale, Naples, Italy) REVERSIBLE AND IRREVERSIBLE ACTIVATION OF TELOMERASES IN HPV-RELATED CANCERS (30 min)

Felicity Burt (Department of Medical Microbiology and Virology, University of the Free State, Bloemfontein, South Africa) ACTIVITY OF LONG CONTROL REGION OF HPV AS DETERMINANT OF ONCOGENICITY

Oral (15 min)

Short oral (10 min)

Discussion & break (5 min)

17.30-18.30 Section 2.2 Chronic viral infections and genomic instability

PLENARY LECTURE Marina Gottikh (Department of Chemistry and Belozersky Institute of Physicochemical Biology, Moscow State University) CHRONIC VIRAL INFECTIONS AND DNA REPAIR SYSTEM OF THE CELL (30 min)

Oral (15 min)

Short oral (10 min)

Discussion & break (5 min)

18.30-20.30 Section 2.3 Viral infections and chronic inflammation

PLENARY LECTURE Nicolas Noel (MCU-PH, Service de Médecine Interne et Immunologie Clinique, GHU Paris Saclay, AP-HP BICÊTRE/CEA 1184, Paris, France) CHRONIC INFLAMMATION IN HIV-1 INFECTION, ARE ELITE CONTROLLERS DIFFERENT? (30 min)

Sona Chowdhury (University of California, San Francisco, USA) PROGRAMMED CELL DEATH PROTEIN 1 (PD-1) AND PROGRAMMED CELL DEATH LIGAND 1 (PD-L1) EXPRESSION PROFILE BY IMMUNE AND EPITHELIAL CELLS IN PRIMARY AND METASTATIC CERVICAL CANCER TISSUES (15 min)

Benoit Favier (DRF-IBFJ-IDMIT, and CEA-University Paris Saclay-Inserm, Fontenay-aux-Roses, France) DYNAMICS OF LILRB2 IMMUNE-CHECKPOINT IN HIV AND SIV INFECTIONS (15 min)

Short oral (10 min)

Short oral (10 min)

PLENARY IN-SIGHT LECTURE Margaret Liu (Protherimmune, and University of California, San Francisco, USA) NUCLEIC ACID VACCINES AND THE POTENTIAL FOR IMPROVING NON-SPECIFIC IMMUNE RESPONSES AND IMMUNE FITNESS FOR CHRONIC INFECTIONS AND CANCER (30 min)

Discussion (10 min)

DAY 2, DECEMBER 17, 2021 13.00-19.45 (GMT+3)

13.00-14.00 SESSION 3. POSTER PRESENTATIONS (5 min orals with PDF/ppt poster viewing)

Posters will be loaded on the web with possibility to also load ppt presentation with recorded text – unlimited. Posters would be available for viewing after the symposium

SESSION 4. IMMUNE RESPONSE TO CHRONIC VIRAL INFECTIONS AND CANCER

14.00-15.30 Section 4.1 Innate and adaptive immunity weak points

PLENARY LECTURE Julia Kzhyshkowska (Institute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany) MACROPHAGES AS VIRAL TARGETS AND RESERVOIRS FOR LONG-TERM SURVIVAL (30 min)

Jorma Hinkula (Linköping University, Linköping, Sweden) IMPAIRMENT OF NK-DC CROSS-TALK AS A COMPONENT OF IMMUNE DYSFUNCTION IN HIV-1 INFECTION (20 min)

Anna Lucia Tornesello & Franco Maria Buonaguro (Istituto Nazionale Tumori – IRCCS Fondazione Pascale, Naples, Italy) PROFILING THE HCV IMMUNE RESPONSE IN PATIENTS WITH HCV-RELATED DISEASES BY PEPTIDE MICROARRAY ANALYSIS (15 min)

Short oral (10 min)

Short oral (10 min)

Discussion & break (5 min)

15.30-17.00 Section 4.2 Immunometabolism of chronic viral infections and cancer

PLENARY LECTURE Ujjwal Neogi (Department of Laboratory Medicine, Karolinska Institute, Stockholm, Sweden) IMMUNE-METABOLIC CHARACTERIZATIONS IN HIV-INFECTION – FROM ELITE CONTROLLERS TO PATIENTS ON LONG-TERM SUCCESSFUL THERAPY (30 min)

PLENARY LECTURE David Finlay (Trinity Colledge Dublin, Ireland) METABOLIC DYSFUNCTION OF NATURAL KILLER CELLS IN CANCER; NUTRIENTS AND METABOLITES PLAY THEIR PART (30 min)

Oral (10 min)

Oral (10 min)

Discussion & break (10 min)

SESSION 5. APPROACHES TO VIRAL INFECTION AND CANCER CURE

17.00-18.30 Section 5.1 Novel viral infection and cancer treatments

PLENARY LECTURE Vladimir Chulanov (National Medical Research Center of Tuberculosis and Infectious Diseases, Moscow, Russia) VIROLOGICAL CURE OF CHRONIC HEPATITIS B INFECTION, FROM “IS IT POSSIBLE?” TO “WHEN?” (30 min)

Isabelle Chemin (Cancer Research Center of Lyon, INSERM, CNRS, Lyon, France) UPDATE ON HEPATOCELLULAR CARCINOMA BREAKTHROUGHS, ACHILLES HEAL FOR PARP INHIBITORS (20 min)

Sofia Nefedorova (Englehard Institute of Molecular Biology, Moscow) EVALUATION OF METABOLIC INHIBITORS AS COMPLEMENTS TO VIROTHERAPY OF SOLID TUMORS (10 min)

Short oral (10 min)

Short oral (10 min)

Discussion & break (10 min)

18.20-20.00 Section 5.2 (Re)profiling of immune response with adjuvants

PLENARY LECTURE Alexandre Corthay (Dept. of Pathology, Oslo University Hospital, and SFF-Hybrid Technology Hub, University of Oslo, Norway) THE TYPE OF IMMUNE RESPONSE IS A CRITICAL FACTOR IN THE IMMUNE BATTLE AGAINST CANCER (30 min)

PLENARY LECTURE

Anna Zajakina (Latvian Biomedical Research and Study Centre, Riga, Latvia) RECOMBINANT VIRAL VECTORS AS ADJUVANTS AND MODULATORS OF IMMUNE RESPONSE FOR CANCER TREATMENT (20 min)

Short oral (10 min)

Short oral (10 min)

CLOSING LECTURE Joon Rhee (Combinatorial Tumor Immunotherapy, Medical Research Center; Department of Microbiology, Chonnam National University Medical School, Chonnam, South Korea) ADJUVANTS FOR CANCER VACCINES (30 min) (negotiated)

Announcement of awards for best oral and poster presentations

Closing of Symposium


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